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As we know, Bioinformatics is the application of information technology and computer science to the field of molecular biology. Its main purpose is to increase our understanding of biological processes, which is why bioinformatics is constantly evolving and reinventing itself through new discoveries and technology. Some of the major research topics in the field of bioinformatics are sequence alignment, gene finding, genome assembly, drug design, drug discovery, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, genome-wide association studies and the modeling of evolution. Continuing our efforts to provide our readers with information that might be of much interest in the simplest possible way, as we have previously done with blogposts such as 10 Science PhD Related Blogs or 10+1 Medical Librarian Blogs.

We thought it would be helpful to share some interesting bioinformatics blogs that can keep you up to date with all kinds of advancements that are being developed in this area and can also help you find information on new software and data mining systems. These are our picks for the Top 15 Bioinformatics Blogs in 2010:

Fisheye Perspective: A Blog about Systems Biology, Bioinformatics, Chemoinformatics, Science and Life in general- by Abhishek Tiwari.

About the author: Abishek Tiwari shares his opinion on issues dealing with bioinformatics. He is a passionate follower of this subject as part of his research interests, studied B.Tech in Bioinformatics in India and is currently getting his PhD in New Zealand.

Description: This blog includes interesting information on other topics such as: chemoinformatics, visual analytics, systems biology, and science as a whole. One of his latest posts, Availability decay of Bioinformatics web resources: Yes widgets can change it, talks about the inaccessibility of bioinformatics software and web resources and how the use of widgets can improve this situation.

Website: http://www.abhishek-tiwari.com

Twitter: @abhishektiwari

What You´re Doing is Rather Desperate: Notes from the life of a bioinformatics researcher

About the Author: Currently located in Australia, Neil Saunders finds a profound joy in science, which he shares through his blog and other publications. The story behind this blog’s name is pretty funny… after Neil gave a speech at work, “come question time, a member of the audience raised her hand and said: It strikes me that what you’re doing is rather desperate. Wouldn’t you be better off doing some experiments?

Description: We find this blog to be very helpful since Neil spreads his knowledge, research, and new findings to all of his followers. You can find useful information on database-related issues when visiting this blog, where you can also ask questions on topics he is currently or has previously been researching such as biotechnology and biomolecular sciences.

Website: http://nsaunders.wordpress.com/

Twitter: @neilfws

Blind Scientist

About the Author: In Paulo Nuin´s website, www.genedrift.org, you can find information on this bioinformatician´s work, research, sample software tools, and more! Paulo Nuin, Brazilian born bioinformatician finds himself in Canada getting his post-doc.

Description: In this blog, Paulo shares his insight on creating simple Python scripts. He is very well-recognized in the bioinformatics field and Python programming and was asked recently to review a Python Beginner guide from Packt Publishing. If you want to read more about it, take a look at Preview of Python Testing’s beginner Guide.

Website: http://blindscientist.genedrift.org/category/bioinformatics-opinion/

Twitter: @nuin

Yokofakun: A blog about bioinformatics, semantic web, comics and social networks

About the Author: A blog mainly about bioinformatics and the semantic web. Pierre Lindenbaum is a brilliant bioinformatician from France who is very active in social networks. He also includes comics in his blog, which he has constantly been working on since 2005.

Description: Yokofakun is highly recognized throughout the bioinformatics community through social networking tools. You can find a lot of information about software and databases, as well as overviews and tips on their use. A perfect example of his work is found in The Path from EgonWillinghagen to Neo4j, a graph API fro java: my notebook. We encourage you to follow this bioinformatics blog where you can find many interesting codes.

Website: http://plindenbaum.blogspot.com/

Twitter: @yokofakun

DigitalBio: discovering biology in a digital world

About the Author: Dr. Sandra Porter, a bioinformatics teacher in Seattle and President of Digital World Biology, writes about things she is learning and discovering about in this field of study, and gives her opinion on current events that are relevant to the subject matter.

Description: In her article, A ScienceOnline 2010 session mash-up review: Fact checking and trust, she analyzes whether Google sites contain misleading information while searching for biomedical terms. We encourage you to visit her site and share your personal opinion with her community.

Website: http://scienceblogs.com/digitalbio/

Twitter: @digitalbio

Your bones got a little machine (Pansapiens): Ideas are cheap, implementation is expensive; act accordingly.

About the Author: Andrew Perry is an Australian structural biologist and bioinformatician, and this blog´s author.

Description: Mainly dealing with structural bioinformatics and biology, the content found in his blog provides interesting information of current events taking place in these fields. If you are also interested in video games, Andrew writes web applications and games mostly through Python programming. During 2009, his activity took place mainly in Friendfeed and not in the blog itself. Here are the 2009 posts that never made it where you can find information on database services, API´s and much more!

Website: http://blog.pansapiens.com/

Twitter: @pansapiens

Saaen Tist: On bioinformatics and personal productivity

About the Author: A blog on bioinformatics and personal productivity by Flemish bioinformatician, Jan Aerts, who describes himself as “a genetics/genomics researcher who accidentally tumbled down the slope of programming and bioinformatics“.

Description: Focuses on relevant database and software technologies, sharing his experience and opinion after using them. In one of his latest posts you can find information on the 1000 genome project, the kind of input data it includes, and how it would look in a database.

Website: http://saaientist.blogspot.com

Twitter: @jandot

Byte Size Biology: The musings and ravings of a computational biologist about science, computers, music and, you know, stuff

About the Author: With about 5 posts per week, Professor Iddo Friedberg from the Miami University in Ohio, keeps us aware of all kinds of facts dealing with the scientific world using a humoristic approach.

Description: Apart from science, this computational biologist also shares his thoughts on computers, music, and other topics. Iddo also recommends his favorite bioinformatics blogs. One of the blogposts we have enjoyed the most is A Sh*tload of Data , where he talks about understanding the role microbiomes play.

Website: http://bytesizebio.net/

Twitter: @iddux

It´s Not Easy being Genes

About the Author: For all of you Python lovers! Chris Lasher provides information related to genetics, bioinformatics, and computational biology, which are all subjects he studies as a graduate student in Virginia Tech.

Description: Check his blog out for tips on the latest technology in Python.

Website: http://igotgenes.blogspot.com/

Twitter: @gotgenes

Manuel Corpas´Blog: Genomes, Internet, Bioethics and More…

About the Author: Manuel Corpas is a Spanish computational biologist who shares his knowledge through his personal blog where you can find information on many related subjects of interest such as biology, biotechnology, computational bioethics, synthetic biology and more, where we find he is “a lead developer of the DECIPHER database, a “DatabasE of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources”. We are delighted to see one of our fellow countrymen so active in the bioinformatics landscape!

Description: You can find posts such as 10 Sarcastic Rules on how to be a Bioinformatician, which not only brings humor to what you are reading but gives you useful tips on how to be at your best. It’s a very reliable source of what goes on in this scientific world.

Website: http://manuelcorpas.com

Twitter: @manuelcorpas

Mailund on the Internet: Computer science, bioinformatics, genetics, and everything in between

About the Author: Thomas Mailund, a research associate professor at the Bioinformatics Research Center in Denmark, is very involved in the bioinformatics world and shares his experiences in conferences and workshops, which he attends, as well as other relevant information on hot topics in this field.

Description: This blog can keep you up to date with information that is emerging in these sessions Mailund participates in. One of his latest posts, which we found to be quite interesting, deals with the evolution of health and medicine .

Website: http://www.mailund.dk/ You can also visit his official work homepage for more information.

Blue Collar Bioinformatics

About the Author: Brad Chapman, biologist and programmer, works in the biology department at Massachusetts General Hospital in Boston. His blog offers support to researchers by answering interesting biological questions, using his personal criteria.

Description: In this site you can find blog posts where he shares information about database systems, genes, and other topics that can be helpful for biologists in their daily functions.

Website:http://bcbio.wordpress.com

Friendfeed: http://friendfeed.com/chapmanb

Mass Genomics: Medical genomics in the post-genome era

About the Author: Dan Koboldt is a highly qualified biologist who works in a Genome Sequencing Center in Washington, and keeps us up to date with this subject through his blog, also sharing his many publications on this interesting topic.

Description: This blog focuses on everything dealing with genomics, just like its name suggests ;) Cancer genomics is one of the subjects he focuses on. In one of his most recent posts, Koboldt points out many concepts and issues that were addressed at sessions in Washington University, such as next generation sequencing and molecular techniques.

Website: http://www.massgenomics.org/

Omics! Omics!:A computational biologist’s personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

About the Author: Computational biologist Keith Robinson has worked on genomic and proteomic technologies, currently working in Massachusetts in the cancer drug discovery field.

Description: Through his blog, Robinson shares his findings by using peculiar examples, which will without a doubt leave you yearning for more. Read his latest post on the possibility of sending synchronous messages to actors…quite entertaining!

Website: http://omicsomics.blogspot.com/

Bonus!

Our #15 Top Pick for bioinformatics blogs is Bio Star available at http://biostar.stackexchange.com/ A site for finding information about bioinformatics, computational genomics, and system biology, containing hundreds of questions and answers on these subjects. It’s an extremely helpful tool, which allows you to interact with other individuals that might have your same interests and doubts regarding bioinformatics. We highly recommend it!

After taking a look at this Top 15 Bioinformatics blogs in 2010, we encourage you to try the novoseek’s API, which we think is a great resource to enrich content, integrate data, and display information in your own format. We are eager to see what skilled bioinformaticians will come up with.
This blog has been adapted from : http://blog.novoseek.com/index.php/blog-coverage/top-15-bioinformatics-blogs-in-2010.html/

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– बिहिवार, 11 मार्च 2010 13:29 दयानन्द बज्राचार्य

सन् १९०२ मा पहिलोपल्ट जर्मन वनस्पतिविज्ञ गोट्लिब हाबरल्यान्डलेे सबै वनस्पतिको कोषबाट सिंगो विरुवाको पुनर्विकास गर्न सकिन्छ भन्ने सिद्धान्त अघि सारेका थिए। सन् १९५० को दशकमा बेलायतका अर्का वनस्पतिविज्ञ एफ. सि. स्टिवार्डले गाजरको एक सूक्ष्म तन्तुबाट प्रयोगशालामा उपयुक्त रसायनको मिश्रण राखिएको परीक्षण नली (टेस्ट ट्युब)मा गाजरको सिंगो बोट पुनर्विकास गरेर हाबरल्यान्डको सिद्धान्तलाई व्यवहारमा प्रमाणित गरेका थिए। ‘टिस्यु कल्चर’ नामले चिनिने उक्त प्रविधिमार्फत् आज कुनै पनि बोटविरुवाको अङ्ग, तन्तु वा कोषबाट प्रयोगशालामा नयाँ विरुवा उत्पादन गर्न सकिन्छ। आज यो प्रविधि कृषि, बागवानी एवं नर्सरीका क्षेत्रमा उन्नत र दुर्लभ जातको बोटविरुवा उत्पादन गर्न व्यापकरूपमा प्रयोग हुँदै आएको छ। यसरी कुनै जीवको अङ्ग, तन्तु वा कोषबाट सोही जीवको पूर्ण प्रतिरूप तयार पार्ने अयौनिक विधिलाई ‘क्लेानिङ’ भनिन्छ। वनस्पति होस् वा प्राणी, सबै जीवको प्रत्येक कोषमा सोही जीवको पुनर्विकास गर्न आवश्यक सम्पूर्ण आनुवंशिक सूचना (जेनेटिक इन्फरमेसन) पाइन्छ भन्ने यथार्थ प्रमाणित भइसकेको छ।
क्लेानिङ प्रविधिमार्फत् बोटविरुवाको पुनर्विकास गर्न सजिलै भए पनि प्राणी र विशेषतः स्तनधारी प्राणीको पुनर्विकास गर्न भने त्यति सरल थिएन। सन् १९९७ मा मात्र स्कटल्यान्डका आएन् विल्मट र उनका सहकर्मी वैज्ञानिकहरू क्लेानिङ प्रविधिमार्फत् एक स्तनधारी प्राणीको प्रतिरूप (क्लोन) निर्माण गर्न सफल भएका थिए। उनीहरूले एक वयस्क भेडीको थुनबाट संकलन गरिएको एक कोषबाट विशेष विधिद्वारा नयाँ भेडीको पूर्ण प्रतिरूप तयार गरेका थिए। ‘डली’ नाम दिइएको उक्त भेडीलाई दुरुस्तै आमाको प्रतिरूपमा उत्पन्न गरिएको थियो। यस प्रविधिबाट मानवको प्रतिरूपसमेत तयार पार्न सकिने सम्भावना देखिएकाले विल्मट र उनका सहकर्मीको उक्त अनुसन्धानले त्यतिबेला विश्वमा ठूलो हलचल मच्चाएको थियो।

विल्मट र उनका सहकर्मीले विकास गरेको क्लोनिङ प्रविधिको प्रयोग गरी वैज्ञानिकहरू मुसा, कुकुर, गाई, उँट, घोडा तथा मानिसको सबैभन्दा नजिकको आनुवंशिक नाता भएको प्राणी मानिने ‘रेसस’ जातको बाँदरजस्ता अरू धेरै प्रकारका स्तनधारी प्राणीको प्रतिरूप तयार पार्न सफल भइसकेका छन्। यस प्रविधिले हजारौं वर्षअघि लोप भइसकेका प्राणीको पुनर्विकास गर्न सकिने सम्भावनाको ढोका उघारेको छ। क्लेानिङ प्रविधिमार्फत् मानवको प्रतिरूपसमेत तयार पार्न सकिने सम्भावना बढेको छ। क्लेानिङ प्रविधि प्रयोग गरी सिद्धान्ततः कुनै पनि मृत वा जीवित मानिसको प्रतिरूप तयार पार्न सकिने देखिन्छ। तथापि अहिलेको अवस्थामा यो काम प्राविधिक दृष्टिकोणले निकै कठिन मानिन्छ। तर हिजो कठिन वा असम्भव देखिएका कतिपय कुरा अहिले वैज्ञानिक यथार्थमा परिणत भएका उदाहरण थुप्रै छन्। तसर्थ मानव क्लोनिङको सम्भावनालाई पूरै नकार्न सकिन्न।

मानव प्रतिरूप तयार पार्नु नैतिक तथा चिकित्सकीय दृष्टिकोणले अनुचित हुने भन्दै युरोप, अमेरिकालगायत विश्वका सबैजसो देशमा मानव क्लोनिङमा प्रतिबन्ध लगाइएको छ। तथापि केही वैज्ञानिकहरू पहिलो मानव शिशुको प्रतिरूप तयार पार्ने होडबाजीमा लागेका हुन् कि भन्ने शंका गरिन्छ। सन् २००३ मा ‘क्लोन एड’ नाम गरेको एक अमेरिकी जैविक प्रविधि कम्पनीले आफ्ना वैज्ञानिकद्वारा ‘इभ’ नाउँकी एक शिशु बालिकाको मानव प्रतिरूप तयार गरिएको दावीसमेत गरेको थियो। कम्पनीले थप प्रतिरूप शिशुको जन्म हुने पनि घोषणा गरेको थियो। वैज्ञानिक स्तरमा यस समाचारको विश्वसनीयताबारे पुष्टि हुन नसकेपनि यसले सञ्चार माध्यममा ठूलै सनसनी फैलाएको थियो र विश्वभर मानव क्लोनिङको मानवीय, चिकित्सकीय र नैतिक पक्ष विपक्षबारे तीव्र बहस सुरु भएको थियो।

मानव क्लोनिङको सम्भावनाले समाजमा आशा र भय दुवै उत्पन्न गरेको छ। यस प्रविधिले अकालमै मृत्यु भएका मानव शिशुको प्रतिरूप तयार गरेर त्यस शिशुको ‘पुनर्जन्म’ समेत गराउने सम्भावना बोकेको छ। यसले कतिपय दुःखीआमाबाबुले आफ्ना गुमेका बच्चा पुनः प्राप्त गर्ने सम्भावना हुन्छ। यस्तो सम्भावनाले समाजका कतिपय व्यक्तिमा ठूलो उत्साहको सञ्चार गरेको छ। यस प्रविधिद्वारा कतिपय मानिस अल्बर्ट आइन्स्टाइनजस्ता अपूर्व बुद्धि र प्रतिभाका प्रतीक मानिने महान् वैज्ञानिकको प्रतिरूप तयार पार्न सकिने सम्भावनाबाट रोमाञ्चित हुने गर्छन् भने, कतिपय मानिस यही प्रविधिबाट एडोल्फ हिटलरजस्ता क्रुर र खतरनाक व्यक्तिको ‘पुनर्जन्म’ हुने आशंकाले भयभीत पनि हुने गर्छन्। के वास्तवमै क्लोनिङ प्रविधिबाट अर्को आइन्स्टाइन वा हिटलरको ‘पुनर्जन्म’ हुन सक्छ? के क्लोनिङ प्रविधिबाट तयार पारिएको कुनै पनि मानव प्रतिरूपको शारीरिक, बौद्धिक र मानसिक स्वभाव दुरुस्त मूल व्यक्ति समान हुन्छ? यस्ता प्रश्नको सही उत्तर प्राप्त गर्न मानिसको समग्र विकासमा आनुवंशिक तत्व (जेनेटिक मटेरियल) र भौतिक तथा सामाजिक वातावरणले खेल्ने भूमिकाबारे चर्चा गर्न आवश्यक हुन्छ।

मानिसबाहेक प्रायः सबैजसो प्राणीको जैविक क्रियाकलाप र व्यवहार मूलतः आमाबाबुबाट प्राप्त वंशाणुगत गुण र ज्ञानबाट निर्देशित हुने गर्छ। तर अन्य प्राणीका तुलनामा स्नायु प्रणाली र मस्तिष्क उच्च विकसित भएकाले मानिसमा आफ्ना आमाबाबुबाट मात्र नभएर आफू हुर्केको भौतिकसामाजिक वातावरणबाट समेत ज्ञान आर्जित गर्ने क्षमता हुन्छ। मानिसमा वर्तमानमात्र नभएर भूतकालको ज्ञानलाई समेत उपयोग गर्ने क्षमता विकास भएको छ, जुन अरू कुनै प्राणीमा पाइँदैन। मानिसले आफूले यसरी हासिल गरेको ज्ञानलाई आफ्नो मस्तिष्कमा धेरै समयसम्म सञ्चित गरी आफ्ना व्यवहारमा अनुकूल परिवर्तन गर्न उचित समयमा पुनः प्रयोग गर्न सक्छन्। त्यसैले मानिसको जैविक क्रियाकलाप र व्यवहार, आमाबाबुबाट प्राप्त वंशाणुगत गुण र ज्ञानका साथै आफूले आर्जन गरेको ज्ञानमा पनि निर्भर हुन्छ।

मानिसको जैविक व्यवहार र आन्तरिक चेतना मूलतः आमाबाबुबाट प्राप्त आनुवंशिक तत्वबाट निर्देशित भएपनि बौद्धिक एवं मानसिक व्यवहार भने भौतिक एवं सामाजिक वातावरणबाट आर्जित ज्ञान र अनुभवबाट बढी प्रभावित हुने विश्वास गरिन्छ। तसर्थ कुनै पनि मानिसको व्यक्तित्व, व्यवहार र बुद्धि उसको वंशाणुगत गुण र ऊ हुर्केको वातावरणको संयुक्त उपज हो। यिनै कारणले गर्दा समान वंशाणुगत गुण भएका तर फरक सामाजिक परिवेशमा हुर्किएका जुम्ल्याहाको शारीरिक रूप र जैविक गुण एकदम समान भए पनि उनीहरूको बौद्धिक र मानसिक स्वभावमा कतिपय भिन्नता पनि पाइन्छ। मानिसको समग्र विकासमा आनुवंशिक तत्व र वातावरणमध्ये कुन पक्ष बढी प्रभावी हुन्छ, किटान गरेर भन्न सकिएको छैन। आनुवंशिक तत्व र वातावरणबीचको सम्बन्ध अत्यन्त जटिल र पेचिलो मानिन्छ।

भनिन्छ, आइन्स्टाइनको मस्तिष्कको केही भाग अझै कतै सुरक्षित छ। आइन्स्टाइनको देहान्तपछि कुनै चिकित्सक वा अनुसन्धाताले आइन्स्टाइनको तीक्ष्ण बुद्धिको रहस्य पत्ता लगाउन गोप्यरूपमा उनको मस्तिष्कका केही भाग रसायनिक घोलमा डुबाएर सुरक्षित गरी राखेको बताइन्छ। हिटलरको मृत शरीरको कुनै अङ्ग आजपनि सु्रक्षित छ वा छैन थाहा छैन। हिटलरको आत्महत्यापछि उनीप्रति वफादार सैनिक जवानले उनको शरीरलाई जलाएर नष्ट गरेको बताइन्छ। तथापि हिटलरको मृत्यु आजपनि रहस्य छ। मृत्युपछि उनको शरीरलाई कतै सुरक्षित ठाउँमा लुकाएर राखिएको छ भन्ने पनि सुनिएको छ।

क्लेानिङका लागि आवश्यक जीवको कोषभित्र पाइने आनुवंशिक तत्व अर्थात् डिएनए अति स्थिर तत्व मानिन्छ। हजाराँै वर्ष पुरानो मृत जीवको कोषबाट संकलित डिएनएलाई समेत वैज्ञानिकहरू पुनः क्रियाशील तुल्याउन सफल भएका छन्। तसर्थ आइन्स्टाइन र हिटलरको मृत शरीरको कुनै अंग वा तन्तु वास्तवमा सुरक्षित छ भने त्यसबाट संकलित कोषको प्रयोगगरी आधुनिक क्लेानिङ प्रविधिमार्फत् सिद्धान्ततः आइन्स्टाइन र हिटलरको प्रतिरूप शिशु तयार गर्न असम्भव देखिंदैन। तर यसरी निर्माण गरिएको आइन्स्टाइनको प्रतिरूप वास्तवमै आइन्स्टाइनजस्तै अपूर्व बुद्धि र प्रतिभासम्पन्न व्यक्तिमा विकसित हुनेछ नै भन्ने निश्चित् चाहिँ छैन। प्रतिरूपमा वैज्ञानिक आइन्स्टाइनकै शतप्रतिशत आनुवंशिक तत्व रहने भएपनि ऊ हुर्किने र बाँच्ने अहिलेको वातावरण र त्यतिबेला आइन्स्टाइन हुर्केका र बाँचेका वातावरणको भौतिक, सामाजिक तथा वैज्ञानिक संरचना भिन्न हुनेछन्। तसर्थ आइन्स्टाइनको प्रतिरूपको व्यवहार र व्यक्तित्व वैज्ञानिक उनको भन्दा नितान्त भिन्न पनि हुन सक्नेछ।

आइन्स्टाइनजस्तै हिटलर पनि उनको आनुवंशिक तत्वको उपजमात्र नभएर त्यसबखत जर्मनी र युरोपमा विद्यमान राजनीतिक एवं आर्थिक-सामाजिक परिस्थितिको परिणाम पनि हुन्। हिटलरको प्रतिरूप हुर्किने आजको विश्वको वातावरण, राजनीतिक एवं आर्थिक-सामाजिक अवस्था हिटलर त्यतिबेला हुर्किएको संसारभन्दा नितान्त फरक छ। तसर्थ हिटलर र उनको प्रतिरूपको व्यवहार पनि फरक हुनेछ र उनीहरू फरक व्यक्ति हुनेछन्।

आधुनिक क्लेानिङ प्रविधिबाट एकैरूप र समान आनुवंशिक तत्व भएका व्यक्तिको निर्माण गर्न सकिएला तर यस प्रविधिबाट तयार पारिएको कुनै पनि मानव प्रतिरूपको व्यवहार र व्यक्तित्व सर्वथा मूल व्यक्ति समान हुन सम्भव छैन। अर्थात्, क्लेानिङ प्रविधिमार्फत् अर्को आइन्स्टाइन वा हिटलरको ‘पुनर्जन्म’ सम्भव छैन।

Source : http://www.nagariknews.com/opinions/98-opinion/11251-2010-03-11-07-46-12.html